Our Expertise

Our Expertise

Since its foundation, Marseille Proteomics (MaP) has been constantly evolving in its areas of expertise to respond to the rapid growth of technologies and methodological approaches observed in recent years in the field of proteomics and mass spectrometry.

MaP's area of expertise encompasses different fields of proteomics, from the description of more or less complex proteomes to the relative quantification of proteins in complex mixtures and identifying post-translational modifications.

The technologies made available enable the identification, characterization (whole mass, sequences, isoforms, post-translational modifications) of proteins, the relative quantitative proteomics by mass spectrometry with or without labelling (TMT, iTRAQ, SILAC / labelFree, DIA), complexomics and interactomics studies, structural proteomics and mass spectrometry imaging.

Protein characterization

  • Identification by mass spectrometry PMF, MS/MS, LC-MS/MS and Edman Sequencing.
  • Analysis of post-translational modifications (phosphorylation, ubiquitinylation, sumoylation, carbonylation, N/O-Glycosylation...) by mass spectrometry.
  • De novo sequencing by mass spectrometry (Top down LC-MS/MS, in source decay MALDI-ToF...) and Edman sequencing.

Quantitative proteomics

  • Quantification by isobaric labelling (iTRAQ, TMT), metabolic labelling (SILAC) and Label-Free.
  • Targeted proteomics using parallel reaction monitoring approach (PRM).
  • Stoechiometry of supramolecular complexes by Edman sequencing or native ESI-MS.

Complexomics and interactomics

  • Biochemical approaches IP-MS, AP-MS, TaP-TaG-MS, APEX-MS and BirA-MS.
  • Non-covalent interactions by native ESI-MS.
  • Characterization by exchange H/D and MS.

Discovery of biomarkers

  • Quantitative proteomics analysis.
  • Research of biomarkers in oncology, immunology, etc.


  • Non-covalent interactions by native ESI-MS.
  • Characterization by H/D exchange and MS/MS analysis.
  • CETSA analysis, drug affinity and click-chemistry.

Structural proteomics

  • Global mass determination of proteins by MALDI or ESI under native or denaturating conditions.
  • Characterization of conformers by ion mobility MS.
  • Flexibility and solvent accessibility by H/D exchange and MS analysis.

Protein fractionation

  • Off gel electrophoresis.
  • High-pressure liquid chromatography (IEX, bRP).
  • 1-D Gel Electrophoresis.

MS Imaging

  • MALDI-Imaging: characterization of biomarkers in situ and distribution of drugs in tissues.


  • Quality control of therapeutic peptides and proteins for the pharmaceutical industry.
  • Characterization of metabolites and pharmacokinetic studies.
  • Quantification of chemicals and drugs by mass spectrometry.


Our Publications By Year


  • Rossotti M, Arceri D, Mansuelle P, Bornet O, Durand A, Ouchane S, Launay H, Dorlet P. The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I). J Inorg Biochem. 2024 May;254:112503. IMM
  • Gerault MA, Granjeaud S, Camoin L, Nordlund P, Dai L. IMPRINTS.CETSA and IMPRINTS.CETSA.app: an R package and a Shiny application forthe analysis and interpretation of IMPRINTS-CETSA data. Brief Bioinform. 2024 Mar 27;25(3):bbae128. CRCM
  • Mouysset B, Le Grand M, Camoin L, Pasquier E. Poly-pharmacology of existing drugs: How to crack the code? Cancer Lett. 2024 Apr 28;588:216800. CRCM
  • Santofimia-Castaño P, Fraunhoffer N, Liu X, Bessone IF, di Magliano MP, Audebert S, Camoin L, Estaras M, Brenière M, Modesti M, Lomberk G, Urrutia R, Soubeyran P, Neira JL, Iovanna J. Targeting NUPR1-dependent stress granules formation to induce synthetic lethalityin Kras(G12D)-driven tumors. EMBO Mol Med. 2024 Mar;16(3):475-505. CRCM
  • Walton A, Thomé V, Revinski D, Marchetto S, Puvirajesinghe TM, Audebert S, Camoin L, Bailly E, Kodjabachian L, Borg JP. A vertebrate Vangl2 translational variant required for planar cell polarity. J Biol Chem. 2024 Feb 24;300(4):106792. CRCM
  • Marbehan X, Roger M, Fournier F, Infossi P, Guedon E, Delecourt L, Lebrun R, Giudici-Orticoni MT, Delaunay S. Combining metabolic flux analysis with proteomics to shed light on the metabolicflexibility: the case of Desulfovibrio vulgaris Hildenborough. Front Microbiol. 2024 Feb 23;15:1336360. IMM
  • Gerault MA, Camoin L, Granjeaud S. DIAgui: a Shiny application to process the output from DIA-NN. Bioinform Adv. 2024 Jan 13;4(1):vbae001. CRCM


  • Leblanc R, Ghossoub R, Goubard A, Castellano R, Fares J, Camoin L, Audebert S, Balzano M, Bou-Tayeh B, Fauriat C, Vey N, Garciaz S, Borg JP, Collette Y, Aurrand-Lions M, David G, Zimmermann P. Downregulation of stromal syntenin sustains AML development. EMBO Mol Med. 2023 Nov 8;15(11):e17570. CRCM
  • Kandolo O, Cherrak Y, Filella-Merce I, Le Guenno H, Kosta A, Espinosa L, Santucci P, Verthuy C, Lebrun R, Nilges M, Pellarin R, Durand E. Acinetobacter type VI secretion system comprises a non-canonical membranecomplex. PLoS Pathog. 2023 Sep 28;19(9):e1011687. IMM
  • Car C, Gilles A, Goujon E, Muller MD, Camoin L, Frelon S, Burraco P, Granjeaud S, Baudelet E, Audebert S, Orizaola G, Armengaud J, Tenenhaus A, Garali I, Bonzom JM, Armant O. Population transcriptogenomics highlights impaired metabolism and smallpopulation sizes in tree frogs living in the Chernobyl Exclusion Zone. BMC Biol. 2023 Jul 31;21(1):164. CRCM
  • Mlayah-Bellalouna S, Aissaoui-Zid D, Chantome A, Jebali J, Souid S, Ayedi E, Mejdoub H, Belghazi M, Marrakchi N, Essafi-Benkhadir K, Vandier C, Srairi-Abid N. Insights into the mechanisms governing P01 scorpion toxin effect against U87glioblastoma cells oncogenesis. Front Pharmacol. 2023 Jun 23;14:1203247. IMM
  • Dron J, Wafo E, Boissery P, Dhermain F, Bouchoucha M, Chamaret P, Lafitte D. Occurrence and distribution of PAHs in stranded dolphin tissues from the Northwestern Mediterranean. Mar Pollut Bull. 2023 Jun;191:114898. PIT2
  • El Kaoutari A, Fraunhoffer NA, Audebert S, Camoin L, Berthois Y, Gayet O, Roques J, Bigonnet M, Bongrain C, Ciccolini J, Iovanna JL, Dusetti NJ, Soubeyran P. Pancreatic ductal adenocarcinoma ubiquitination profiling reveals specific prognostic and theranostic markers. EBioMedicine. 2023 May 29;92:104634. CRCM
  • Kernalléguen A, Kintz P, Leonetti G, Lafitte D, Pélissier-Alicot AL. Recent Trends in MALDI-MS Drugs Analysis in Human Hair: Pre-Analytical and Analytical Challenges and Pitfalls. J Anal Toxicol. 2023 May 19;47(5):417-428. PIT2
  • Arcanjo C, Frelon S, Armant O, Camoin L, Audebert S, Camilleri V, Cavalié I, Adam-Guillermin C, Gagnaire B. Insights into the modes of action of tritium on the early-life stages of zebrafish, Danio rerio, using transcriptomic and proteomic analyses. J Environ Radioact. 2023 May;261:107141. CRCM
  • Ruminski K, Celis-Gutierrez J, Jarmuzynski N, Maturin E, Audebert S, Malissen M, Camoin L, Voisinne G, Malissen B, Roncagalli R. Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway. Front Immunol. 2023 Mar 15;14:1139123. CRCM
  • Kpebe A, Guendon C, Payne N, Ros J, Khelil Berbar M, Lebrun R, Baffert C, Shintu L, Brugna M. An essential role of the reversible electron-bifurcating hydrogenase Hnd for ethanol oxidation in Solidesulfovibrio fructosivorans. Front. Microbiol. 2023 March. IMM
  • Prioretti L, D’Ermo G, Infossi P, Kpebe A, Lebrun R, Bauzan M, Lojou E, Guigliarelli B, Giudici-Orticoni M-T, Guiral M. Carbon Fixation in the Chemolithoautotrophic Bacterium Aquifex aeolicus Involves Two Low-Potential Ferredoxins as Partners of the PFOR and OGOR Enzymes. Life 2023 Feb 23;13(3):627. IMM


  • González García MC, Radix C, Villard C, Breuzard G, Mansuelle P, Barbier P, Tsvetkov PO, De Pomyers H, Gigmes D, Devred F, Kovacic H, Mabrouk K, Luis J. Myotoxin-3 from the Pacific Rattlesnake Crotalus oreganus oreganus Venom Is a New Microtubule-Targeting Agent. Molecules 2022 Nov 25;27(23):8241. IMM
  • Barelier S, Avellan R, Gnawali GR, Fourquet P, Roig-Zamboni V, Poncin I, Point V, Bourne Y, Audebert S, Camoin L, Spilling CD, Canaan S, Cavalier JF, Sulzenbacher G. Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis. FEBS J. 2022 Oct 5. CRCM
  • Masi M, Vergalli J, Ghai I, Barba-Bon A, Schembri T, Nau WM, Lafitte D, Winterhalter M, Pagès JM. Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane. Commun Biol. 2022 Oct 5;5(1):1059. PiT2
  • Zhang A, Lebrun R, Espinosa L, Galinier A, Pompeo F. PrkA is an ATP-dependent protease that regulates sporulation in Bacillus subtilis. J Biol Chem. 2022 Aug 27:102436. IMM
  • Daulat AM, Wagner MS, Audebert S, Kowalczewska M, Ariey-Bonnet J, Finetti P, Bertucci F, Camoin L, Borg JP. The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins. J Cell Sci. 2022 Aug 16:jcs.259347. CRCM
  • Le TK, Cherif C, Omabe K, Paris C, Lannes F, Audebert S, Baudelet E, Hamimed M, Barbolosi D, Finetti P, Bastide C, Fazli L, Gleave M, Bertucci F, Taïeb D, Rocchi P. DDX5 mRNA-targeting Antisense Oligonucleotide as a new promising therapeutic in combating Castration-Resistant Prostate Cancer. Mol Ther. 2022 Aug 13:S1525-0016(22)00493-2. CRCM
  • Nigri J, Leca J, Tubiana SS, Finetti P, Guillaumond F, Martinez S, Lac S, Iovanna JL, Audebert S, Camoin L, Vasseur S, Bertucci F, Tomasini R. CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness. Sci Signal. 2022 Aug 2;15(745):eabg8191. CRCM
  • Santofimia-Castaño P, Huang C, Liu X, Xia Y, Audebert S, Camoin L, Peng L, Lomberk G, Urrutia R, Soubeyran P, Neira JL, Iovanna J. NUPR1 protects against hyperPARylation-dependent cell death. Commun Biol. 2022 Jul 22;5(1):732. CRCM
  • Le Goff M, Vastel M, Lebrun R, Mansuelle P, Diarra A, Grandjean T, Triponney P, Imbert G, Gosset P, Dessein R, Garnier F, Durand E. Characterization of the Achromobacter xylosoxidans Type VI Secretion System and Its Implication in Cystic Fibrosis. Front Cell Infect Microbiol. 2022 Jun 16;12:859181. IMM
  • Gérard, C, Lebrun, R, Lemesle, E, Avilan, L, Chang, K.S, Jin, E,  Carrière, F,  Gontero, B, Launay, H. Reduction in Phosphoribulokinase Amount and Re-Routing Metabolism in Chlamydomonas reinhardtii CP12 Mutants. Int. J. Mol. Sci. 2022, 23, 2710. IMM
  • Gouirand V, Gicquel T, Lien EC, Jaune-Pons E, Da Costa Q, Finetti P, Metay E, Duluc C, Mayers JR, Audebert S, Camoin L, Borge L, Rubis M, Leca J, Nigri J, Bertucci F, Dusetti N, Lucio Iovanna J, Tomasini R, Bidaut G, Guillaumond F, Vander Heiden MG, Vasseur S. Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression. EMBO J. 2022 Mar 21:e110466. CRCM
  • Guervilly JH, Blin M, Laureti L, Baudelet E, Audebert S, Gaillard PH. SLX4 dampens MutSα-dependent mismatch repair. Nucleic Acids Res. 2022 Feb 15. CRCM
  • Payne N, Kpebe A, Guendon C, Baffert C, Ros J, Lebrun R, Denis Y, Shintu L, Brugna M. The electron-bifurcating FeFe-hydrogenase Hnd is involved in ethanol metabolism in Desulfovibrio fructosovorans grown on pyruvate. Mol Microbiol. 2022 Jan 23. IMM
  • Pesce G, Gondelaud F, Ptchelkine D, Nilsson JF, Bignon C, Cartalas J, Fourquet P, Longhi S. Experimental Evidence of Intrinsic Disorder and Amyloid Formation by the Henipavirus W Proteins. Int J Mol Sci. 2022 Jan 15;23(2):923. CRCM
  • Costa MM, Martin H, Estellon B, Dupé FX, Saby F, Benoit N, Tissot-Dupont H, Million M, Pradines B, Granjeaud S, Almeras L. Exploratory Study on Application of MALDI-TOF-MS to Detect SARS-CoV-2 Infection in Human Saliva. J Clin Med. 2022 Jan 6;11(2):295. CRCM


  • Berestjuk I, Lecacheur M, Carminati A, Diazzi S, Rovera C, Prod'homme V, Ohanna M, Popovic A, Mallavialle A, Larbret F, Pisano S, Audebert S, Passeron T, Gaggioli C, Girard CA, Deckert M, Tartare-Deckert S. Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma. EMBO Mol Med. 2021 Dec 27:e11814. CRCM
  • Mangon A, Salaün D, Bouali ML, Kuzmić M, Quitard S, Thuault S, Isnardon D, Audebert S, Puech PH, Verdier-Pinard P, Badache A. iASPP contributes to cell cortex rigidity, mitotic cell rounding, and spindle positioning. J Cell Biol. 2021 Dec 6;220(12):e202012002. CRCM
  • Dron J, Wafo E, Boissery P, Dhermain F, Bouchoucha M, Chamaret P, Lafitte D. Trends of banned pesticides and PCBs in different tissues of striped dolphins (Stenella coeruleoalba) stranded in the Northwestern Mediterranean reflect changing contamination patterns. Mar Pollut Bull. 2021 Dec 4;174:113198. PIT2
  • Arias-Cartin R,  Uzel A,  Seduk F,  Gerbaud G,  Pierre F, Broc M, Lebrun R,  Guigliarelli B, Magalon A,  Grimaldi S, Walburger A. Identification and characterization of a non-canonical menaquinone-linked formate dehydrogenase. J Biol Chem. 2021 Nov 5:101384. IMM
  • Delisle J, Cordier B, Audebert S, Pophillat M, Cluzel C, Espinosa L, Grangeasse C, Galinier A, Doan T. Characterization of TseB: A new actor in cell wall elongation in Bacillus subtilis. Mol Microbiol. 2021 Oct;116(4):1099-1112. CRCM
  • Lee L, Perez Oliva AB, Martinez-Balsalobre E, Churikov D, Peter J, Rahmouni D, Audoly G, Azzoni V, Audebert S, Camoin L, Mulero V, Cayuela ML, Kulathu Y, Geli V, Lachaud C. UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival. Sci Adv. 2021 Sep 24;7(39). CRCM
  • Costa MM, Benoit N, Tissot-Dupont H, Million M, Pradines B, Granjeaud S, Almeras L. Mouth Washing Impaired SARS-CoV-2 Detection in Saliva. Diagnostics (Basel). 2021 Aug 22;11(8):1509 CRCM
  • Iv F, Martins CS, Castro-Linares G, Taveneau C, Barbier P, Verdier-Pinard P, Camoin L, Audebert S, Tsai FC, Ramond L, Llewellyn A, Belhabib M, Nakazawa K, Di Cicco A, Vincentelli R, Wenger J, Cabantous S, Koenderink GH, Bertin A, Mavrakis M. Insights into animal septins using recombinant human septin octamers with distinct SEPT9 isoforms. J Cell Sci. 2021 Aug 1;134(15):jcs258484. CRCM
  • Costa MM, Benoit N, Saby F, Pradines B, Granjeaud S, Almeras L. Optimization and Standardization of Human Saliva Collection for MALDI-TOF MS. Diagnostics (Basel). 2021 Jul 21;11(8):1304. CRCM
  • Nguyen DT, Le TK, Paris C, Cherif C, Audebert S, Udu-Ituma SO, Benizri S, Barthélémy P, Bertucci F, Taïeb D, Rocchi P. Antisense Oligonucleotide-Based Therapeutic against Menin for Triple-Negative Breast Cancer Treatment. Biomedicines. 2021 Jul 8;9(7):795. CRCM
  • Adjuto-Saccone M, Soubeyran P ,Garcia J, Audebert  S, Camoin  L, Rubis  M, Roques J, Binétruy B, Iovanna JL, Tournaire R. TNF-α induces endothelial-mesenchymal transition promoting stromal development of pancreatic adenocarcinoma. Cell Death Dis. 2021 Jun 25;12(7):649. CRCM
  • Torrino S, Grasset EM, Audebert S, Belhadj I, Lacoux C, Haynes M, Pisano S, Abélanet S, Brau F, Chan SY, Mari B, Oldham WM, Ewald AJ, Bertero T. Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis. Cell Metab. 2021 May 31:S1550-4131(21)00226-6. CRCM
  • Launay H, Shao H, Bornet O, Cantrelle FX, Lebrun R, Receveur-Brechot V, Gontero B. Flexibility of Oxidized and Reduced States of the Chloroplast Regulatory Protein CP12 in Isolation and in Cell Extracts. Biomolecules. 2021 May 8;11(5):701. IMM
  • Daulat AM, Audebert S, Wagner M, Camoin L, Borg JP. Identification of PDZ Interactions by Affinity Purification and Mass Spectrometry Analysis. Methods Mol Biol. 2021;2256:17-40. CRCM
  • Melo Costa M, Benoit N, Dormoi J, Amalvict R, Gomez N, Tissot-Dupont H, Million M, Pradines B, Granjeaud S, Almeras L. Salivette, a relevant saliva sampling device for SARS-CoV-2 detection. J Oral Microbiol. 2021 Apr 30;13(1):1920226 CRCM
  • Lavalou J, Mao Q, Harmansa S, Kerridge S, Lellouch AM, Philippe JM, Audebert S, Camoin L, Lecuit T. Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry. Dev Cell. 2021 Apr 27;S1534-5807(21)00270-7. CRCM
  • He L, Valignat MP, Zhang L, Gelard L, Zhang F, Le Guen V, Audebert S, Camoin L, Fossum E, Bogen B, Wang H, Henri S, Roncagalli R, Theodoly O, Liang Y, Malissen M, Malissen B. ARHGAP45 controls naïve T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding. EMBO Rep. 2021 Apr 7;22(4):e52196. CRCM
  • Shao H, Huang W, Avilan L, Receveur-Bréchot V, Puppo C, Puppo R, Lebrun R, Gontero B, Launay H. A new type of flexible CP12 protein in the marine diatom Thalassiosira pseudonana. Cell Commun Signal. 2021 Mar 24;19(1):38. IMM
  • Yacoubi I, Hamdi K, Fourquet P, Bignon C, Longhi S. Structural and Functional Characterization of the ABA-Water Deficit Stress Domain from Wheat and Barley: An Intrinsically Disordered Domain behind the Versatile Functions of the Plant Abscissic Acid, Stress and Ripening Protein Family. Int J Mol Sci. 2021 Feb 26;22(5):2314. CRCM
  • Avilan L, Lebrun R, Puppo C, Citerne S, Cuiné S, Li-Beisson Y, Menand B, Field B, Gontero B. ppGpp influences protein protection, growth and photosynthesis in Phaeodactylum tricornutum. New Phytol. 2021 Feb 17. IMM
  • Colin F, Schauer K, Hamiche A, Martineau P, Borg JP, Bednar J, Bertolin G, Camoin L, Collette Y, Dimitrov S, Fournier I, Hyenne V, Mendoza-Parra MA, Morelli X, Rondé P, Sumara I, Tramier M, Schultz P, Goetz JG. The NANOTUMOR consortium - Towards the Tumor Cell Atlas. Biol Cell. 2021 Feb 7. CRCM


  • Golovin AV, Devred F, Yatoui D, Roman AY, Zalevsky AO, Puppo R, Lebrun R, Guerlesquin F, Tsvetkov PO. Zinc Binds to RRM2 Peptide of TDP-43. Int J Mol Sci. 2020 Nov 29;21(23):9080. IMM
  • Arechederra M, Bazai SK, Abdouni A, Sequera C, Mead TJ, Richelme S, Daian F, Audebert S, Dono R, Lozano A, Gregoire D, Hibner U, Allende DS, Apte SS, Maina F. ADAMTSL5 is an epigenetically activated gene underlying tumorigenesis and drug resistance in hepatocellular carcinoma. J Hepatol. 2020 Nov 13;S0168-8278(20)33758-2. CRCM
  • Cavalier JF, Spilling CD, Durand T, Camoin L, Canaan S. Lipolytic enzymes inhibitors: A new way for antibacterial drugs discovery. Eur J Med Chem. 2020 Oct 12:112908. CRCM
  • Santoni MJ, Kashyap R,Camoin L Borg JP. The Scribble family in cancer: twentieth anniversary. Oncogene 2020 Sep 30:1-15. CRCM
  • Madani A, Mallick I, Guy A, Crauste C, Durand T, Fourquet P, Audebert S, Camoin L, Canaan S, Cavalier JF. Dissecting the antibacterial activity of oxadiazolone-core derivatives against Mycobacterium abscessus. PLoS One 2020 Sep 18;15(9):e0238178. CRCM
  • Platsaki S, Zhou X, Pinan-Lucarré B, Delauzun V, Tu H, Mansuelle P, Fourquet P, Bourne Y, Bessereau JL, Marchot P. The Ig-like domain of Punctin/MADD-4 is the primary determinant for interaction with the ectodomain of neuroligin NLG-1. J Biol Chem . 2020 Sep 14:jbc.RA120.014591 IMM/CRCM
  • Lan W, Santofimia-Castaño P, Swayden M, Xia Y, Zhou Z, Audebert S, Camoin L, Huang C, Peng L, Jiménez-Alesanco A, Velázquez-Campoy A, Abian O, Lomberk G, Urrutia R, Rizzuti B, Geli V, Soubeyran P, Neira JL, Iovanna JL. ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents. JCI Insight. 2020 Aug 11:138117. CRCM
  • Girard CA, Lecacheur M, Ben Jouira R, Berestjuk I, Diazzi S, Prod'homme V, Mallavialle A, Larbret F, Gesson M, Schaub S, Pisano S, Audebert S, Mari B, Gaggioli C, Leucci E, Marine JC, Deckert M, Tartare-Deckert S.  A feed-forward mechanosignaling loop confers resistance to therapies targeting the MAPK pathway in BRAF-mutant melanoma. Cancer Res. 2020 May 15;80(10):1927-1941. CRCM
  • Takedachi A, Despras E,, Scaglione S, Guérois R, Guervilly J H, Blin J H, Audebert S, Camoin L, Hasanova Z, Schertzer M, Guille A, Churikov D, Callebaut I, Naim I, Chaffanet M, Borg J P, F Bertucci , Revy P, Birnbaum D, Londoño-Vallejo A, Kannouche P L, Gaillard P H L. SLX4 Interacts With RTEL1 To Prevent Transcription-Mediated DNA Replication Perturbations. Nat Struct Mol Biol. 2020 May;27(5):438-449. CRCM
  • Thuault S, Mamelonet C, Salameh J, Ostacolo K, Chanez B, Salaün D, Baudelet E, Audebert S, Camoin L, Badache A. A proximity-labeling proteomic approach to investigate invadopodia molecular landscape in breast cancer cells. Sci Rep. 2020 Apr 22;10(1):6787. CRCM
  • Ghossoub R, Chéry M, Audebert S, Leblanc R, Egea-Jimenez AL, Lembo F, Mammar S, Le Dez F, Camoin L, Borg JP, Rubinstein E, David G, Zimmermann P. Tetraspanin-6 negatively regulates exosome production. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5913-5922. CRCM
  • Chalier F, Mugnier L, Tarbe M, Aboudou S, Villard C, Kovacic H, Gigmes D, Mansuelle P, de Pomyers H, Luis J, and Mabrouk, K. Isolation of an Anti-Tumour Disintegrin: Dabmaurin-1, a Peptide Lebein-1-Like, from Daboia mauritanica Venom. Toxins (Basel) 2020 Feb 5;12(2). IMM
  • Salhi A, Amara S, Mansuelle P, Puppo R, Lebrun R, Gontero B, Aloulou A, Carrière F. Characterization of all the lipolytic activities in pancreatin and comparison with porcine and human pancreatic juices. Biochimie. 2020 Feb;169:106-120. IMM
  • Canestrari MJ, Serrano B, Bartoli J, Prima V, Bornet O, Puppo R, Bouveret E, Guerlesquin F, and Viala JP. Deciphering the specific interaction between the acyl carrier protein IacP and the T3SS-major hydrophobic translocator SipB from Salmonella. FEBS Lett. 2020 Jan;594(2):251-265. IMM
  • Roumezi B, Xu X, Risou V, Fan Y, Lebrun R, Latifi A. The Pkn22 kinase of Nostoc PCC 7120 is required for cell differentiation via the phosphorylation of HetR on a residue highly conserved in genomes of heterocyst-forming cyanobacteria. Front. Microbiol. 2020 Jan 21;10:3140. IMM


  • Murat El Houdigui S, Adam-Guillermin C, Loro G, Arcanjo C, Frelon S, Floriani M, Dubourg N, Baudelet E, Audebert S, Camoin L, Armant O. A systems biology approach reveals neuronal and muscle developmental defects after chronic exposure to ionising radiation in zebrafish. Sci Rep. 2019 Dec 27;9(1):20241. CRCM
  • Swayden M, Dobric A, Berthois Y, Villalba H, Audebert S, Camoin L, Iovanna J, Soubeyran P. Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational ModIFications and IdentIFication of Significant Alterations. J Vis Exp. 2019 Nov 7;(153). CRCM
  • Bulot S, Audebert S, Pieulle L, Seduk F, Baudelet E, Espinosa L, Pizay MC, Camoin L, Magalon A. Clustering as a Means To Control Nitrate Respiration Efficiency and Toxicity in Escherichia coli. MBio. 2019 Oct 22;10(5). CRCM
  • Katsogiannou M, Boyer JB, Valdeolivas A, Remy E, Calzone L, Audebert S, Rocchi P, Camoin L, Baudot A. Integrative proteomic and phosphoproteomic profiling of prostate cell lines. PLoS One 2019 Nov 1;14(11):e0224148. CRCM
  • Garciaz S, N'guyen Dasi L, Finetti P, Chevalier C, Vernerey J, Poplineau M, Platet N, Audebert S, Pophillat M, Camoin L, Bertucci F, Calmels B, Récher C, Birnbaum D, Chabannon C, Vey N, Duprez E. Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation. Clin Epigenetics. 2019, 12;11(1):141. CRCM
  • Fournier E, Tachon S, Fowler NJ, Gerbaud G, Mansuelle P, Dorlet P, de Visser SP, Belle V, Simaan AJ, Martinho M. The Hunt for the Closed Conformation of the Fruit-Ripening Enzyme 1-Aminocyclopropane-1-carboxylic Oxidase: A Combined Electron Paramagnetic Resonance and Molecular Dynamics Study. Chemistry. 2019 Oct 28;25(60):13766-13776. IMM
  • Swayden M, Alzeeb G, Masoud R, Berthois Y, Audebert S, Camoin L, Hannouche L, Vachon H, Gayet O, Bigonnet M, Roques J, Silvy F, Carrier A, Dusetti N, Iovanna JL, Soubeyran P. PML hyposumoylation is responsible for the resistance of pancreatic cancer. FASEB J. 2019 16:fj201901091R. CRCM
  • Daulat AM, Wagner MS, Walton A, Baudelet E, Audebert S, Camoin L, Borg JP. The Tumor Suppressor SCRIB is a Negative Modulator of the Wnt/β-Catenin Signaling Pathway. Proteomics. 2019 12:e1800487. CRCM
  • Tachon S, Fournier E, Decroos C, Mansuelle P, Etienne E, Maresca M, Martinho M, Belle V, Tron T, Simaan AJ. Chemical Modification of 1-Aminocyclopropane Carboxylic Acid (ACC) Oxidase: Cysteine Mutational Analysis, Characterization, and Bioconjugation with a Nitroxide Spin Label. Mol Biotechnol. 2019 Jun 14. IMM
  • Duhoo Y, Girault V, Turchetto J, Ramond L, Durbesson F, Fourquet P, Nominé Y, Cardoso V, Sequeira AF, Brás JLA, Fontes CMGA, Travé G, Wolff N, Vincentelli R High-Throughput Production of a New Library of Human Single and Tandem PDZ Domains Allows Quantitative PDZ-Peptide Interaction Screening Through High-Throughput Holdup Assay. Methods Mol Biol. 2019;2025:439-476. CRCM
  • Rathore M, Girard C, Ohanna M, Tichet M, Ben Jouira R, Garcia E, Larbret F, Gesson M, Audebert S, Lacour JP, Montaudié H, Prod'Homme V, Tartare-Deckert S, Deckert M. Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway. Oncogene. 2019 Jun 28. CRCM
  • Madani A, Ridenour JN, Martin BP, Paudel RR, Abdul Basir A, Le Moigne V, Herrmann JL, Audebert S, Camoin L, Kremer L, Spilling CD, Canaan S, Cavalier JF. Cyclipostins and Cyclophostin analogs are multi-target inhibitors that impair growth of Mycobacterium abscessus. ACS Infect Dis 2019 Jul 12. CRCM
  • Fey P, Bustamante P, Bosserelle P, Espiau B, Malau A, Mercader M, Wafo E, Letourneur Y. Does trophic level drive organic and metallic contamination in coral reef organisms? Sci Total Environ. 2019 Jun 1;667:208-221 PIT2
  • Jiang HS, Zhang Y, Lu ZW, Lebrun R, Gontero B, Li W. Interaction between Silver Nanoparticles and Two Dehydrogenases: Role of Thiol Groups. Small 2019 May 21. IMM
  • Dubois C, Pophillat M, Audebert S, Fourquet P, Lecomte C, Dubourg N, Galas S, Camoin L, Frelon S. Differential modification of the C. elegans proteome in response to acute and chronic gamma radiation: Link with reproduction decline. Sci Total Environ. 2019 Aug 1. CRCM
  • Soubéran A, Cappaï J, Chocry M, Nuccio C, Raujol J, Colin C, Lafitte D, Kovacic H, Quillien V, Baeza-Kallee N, Rougon G, Figarella-Branger D, Tchoghandjian A. Inhibitor of Apoptosis Proteins Determine Glioblastoma Stem-Like Cells Fate in an Oxygen-Dependent Manner. Stem Cells. 2019 Mar 28. PiT2
  • Daulat AM, Finetti P, Revinski D, Silveira Wagner M, Camoin L, Audebert S, Birnbaum D, Kodjabachian L, Borg JP, Bertucci F. ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer. Br J Cancer 2019 Apr 11. CRCM
  • Torres-Gutiérrez E, Pérez-Cervera Y, Camoin L, Zenteno E, Aquino-Gil MO, Lefebvre T, Cabrera-Bravo M, Reynoso-Ducoing O, Bucio-Torres MI, Salazar-Schettino PM. Identification of O-Glcnacylated Proteins in Trypanosoma cruzi. Front Endocrinol (Lausanne) 2019 Mar 29;10:199. CRCM
  • Kamoun J, Rahier R, Sellami M, Koubaa I, Mansuelle P, Lebrun R, Berlioz-Barbier A, Fiore M, Alvarez K, Abousalham A, Carrière F, Aloulou A. Identification of a new natural gastric lipase inhibitor from star anise. Food Funct. 2019 Jan 22;10(1):469-478. IMM


  • Minas IS, Tanou G, Krokida A, Karagiannis E, Belghazi M, Vasilakakis M, Papadopoulou KK, Molassiotis A Ozone-induced inhibition of kiwifruit ripening is amplified by 1-methylcyclopropene and reversed by exogenous ethylene. BMC Plant Biol. 2018 Dec 17 CRN2M
  • Kernalléguen A, Enjalbal C, Alvarez JC, Belgacem O, Léonetti G, Lafitte D, Pélissier-Alicot AL. Synthetic cannabinoid isomers characterization by MALDI-MS3 imaging: Application to single scalp hair. Anal Chim Acta. 2018 Dec 24 PIT2
  • Sams L, Amara S, Mansuelle P, Puppo R, Lebrun R, Paume J, Giallo J, Carrière F. Characterization of pepsin from rabbit gastric extract, its action on β-casein and the effects of lipids on proteolysis. Food Funct. 2018 Oct 31. IMM
  • Lebellec L, Bertucci F, Tresch-Bruneel E, Ray-Coquard I, Le Cesne A, Bompas E, Blay JY, Italiano A, Mir O, Ryckewaert T, Toiron Y, Camoin L, Goncalves A, Penel N, Le Deley MC. Prognostic and predictive factors for angiosarcoma patients receiving paclitaxel once weekly plus or minus bevacizumab: an ancillary study derived from a randomized clinical trial. BMC Cancer. r2018 Oct 11 CRCM
  • Guerin M, Gonçalves A, Toiron Y, Baudelet E, Pophillat M, Granjeaud S, Fourquet P, Jacot W, Tarpin C, Sabatier R, Agavnian E, Finetti P, Adelaide J, Birnbaum D, Ginestier C, Charafe-Jauffret E, Viens P, Bertucci F, Borg JP, Camoin L. Development of parallel reaction monitoring (PRM)-based quantitative proteomics applied to HER2-Positive breast cancer. Oncotarget. 2018 Sep 18 CRCM
  • Nguyen PC, Nguyen VS, Martin BP, Fourquet P, Camoin L, Spilling CD, Cavalier JF, Cambillau C, Canaan S. Biochemical and Structural Characterization of TesA, a Major Thioesterase Required for Outer-Envelope Lipid Biosynthesis in M. tuberculosis. J Mol Biol. 2018 Oct 4 CRCM
  • Santin YG, Doan T, Lebrun R, Espinosa L, Journet L, Cascales E. In vivo TssA proximity labelling during type VI secretion biogenesis reveals TagA as a protein that stops and holds the sheath. Nat Microbiol. 2018 Oct 1. IMM
  • Gagnoux-Palacios L, Awina H, Audebert S, Rossin A, Mondin M, Borgese F, Planas-Botey C, Mettouchi A, Borg JP, Hueber AO. Cell polarity and adherens junction formation inhibit epithelial Fas cell death receptor signaling. J Cell Biol. 2018 Sep 21 CRCM
  • Martin-Eauclaire MF, Salvatierra J, Mansuelle P, Bosmans F, Bougis PE. The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension. FEBS Lett. 2018 Aug;592(15):2668. CRN2M
  • Rama S, Boumedine-Guignon N, Sangiardi M, Youssouf F, Maulet Y, Lévêque C, Belghazi M, Seagar M, Debanne D, El Far O. Chromophore-Assisted Light Inactivation of the V-ATPase V0c Subunit Inhibits Neurotransmitter Release Downstream of Synaptic Vesicle Acidification. Mol Neurobiol. 2018 Aug 28. CRN2M
  • Nguyen PC, Delorme V, Bénarouche A, Guy A, Landry V, Audebert S, Pophillat M, Camoin L, Crauste C, Galano JM, Durand T, Brodin P, Canaan S, Cavalier JF. Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis. Bioorg Chem. 2018 Aug 29 CRCM
  • Zhang Y, Launay H, Schramm A, Lebrun R, Gontero B. Exploring intrinsically disordered proteins in Chlamydomonas reinhardtii. Sci Rep. 8(1):6805 IMM
  • Deracinois B, Camoin L, Lambert M, Boyer JB, Dupont E, Bastide B, Cieniewski-Bernard C. O-GlcNAcylation site mapping by (azide-alkyne) click chemistry and mass spectrometry following intensive fractionation of skeletal muscle cells proteins. J Proteomics. 2018 Jul 14 CRCM
  • Zhang Y, Launay H, Liu F, Lebrun R, Gontero B Interaction between adenylate kinase 3 and glyceraldehyde-3-phosphate dehydrogenase from Chlamydomonas reinhardtii. FEBS J. 2018 May 4. IMM
  • Wang X, Roger M, Clément R, Lecomte S, Biaso F, Abriata LA, Mansuelle P, Mazurenko I, Giudici-Orticoni MT, Lojou E, Ilbert M. Electron transfer in an acidophilic bacterium: interaction between a diheme cytochrome and a cupredoxin. Chem Sci. 2018 May 1 IMM
  • Krayem N, Parsiegla G, Gaussier H, Louati H, Jallouli R, Mansuelle P, Carrière F, Gargouri Y Functional characterization and FTIR-based 3D modeling of full length and truncated forms of Scorpio maurus venom phospholipase A2. Biochim Biophys Acta. 2018 May IMM
  • Ouertani A, Chaabouni I, Mosbah A, Long J, Barakat M, Mansuelle P, Mghirbi O, Najjari A, Ouzari HI, Masmoudi AS, Maresca M, Ortet P, Gigmes D, Mabrouk K, Cherif A Two New Secreted Proteases Generate a Casein-Derived Antimicrobial Peptide in Bacillus cereus Food Born Isolate Leading to Bacterial Competition in Milk. Front Microbiol. 2018 Jun 4 IMM
  • Tissot FS, Estrach S, Boulter E, Cailleteau L, Tosello L, Seguin L, Pisano S, Audebert S, Croce O, Féral CC Dermal fibroblast SLC3A2 deficiency leads to premature aging and loss of epithelial homeostasis J Invest Dermatol. 2018 Jun 12 CRCM
  • Daulat AM, Puvirajesinghe TM, Camoin L, Borg JP. Mapping cellular polarity networks using mass spectrometry-based strategies. J Mol Biol. 2018 May 18. CRCM
  • Loret EP, Luis J, Nuccio C, Villard C, Mansuelle P, Lebrun R, Villard PH. A Low Molecular Weight Protein from the Sea Anemone Anemonia viridis with an Anti-Angiogenic Activity. Mar Drugs. 2018 Apr 19;16(4) IMM
  • Peltier J, Roperch JP, Audebert S, Borg JP, Camoin L. Activation peptide of the coagulation factor XIII (AP-F13A1) as a new biomarker for the screening of colorectal cancer. Clin Proteomics. 2018 Apr 9;15:15. CRCM
  • Kernalléguen A, Steinhoff R, Bachler S, Dittrich PS, Saint-Marcoux F, El Balkhi S, Vorspan F, Leonetti G, Lafitte D, Pélissier-Alicot AL, Zenobi R. High-Throughput Monitoring of Cocaine and its Metabolites in Hair Using Microarrays for Mass Spectrometry and MALDI-MS/MS. Anal Chem. 2018 Jan 8. PIT2
  • Mokart D, Saillard C, Zemmour C, Bisbal M, Sannini A, Chow-Chine L, Brun JP, Faucher M, Boher JM, Toiron Y, Chabannon C, Borg JP, Gonçalves A, Camoin L. Early prognostic factors in septic shock cancer patients: a prospective study with a proteomic approach. Acta Anaesthesiol Scand. 2018 Jan 7 CRCM
  • Viljoen A, Richard M, Nguyen PC, Fourquet P, Camoin L, Paudal RR, Gnawali GR, Spilling CD, Cavalier JF, Canaan S, Blaise M, Kremer L. Cyclipostins and Cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo. J Biol Chem. 2018 Jan 4. CRCM


  • Nguyen PC, Delorme V, Bénarouche A, Martin BP, Paudel R, Gnawali GR, Madani A, Puppo R, Landry V, Kremer L, Brodin P, Spilling CD, Cavalier JF, Canaan S. Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis. Sci Rep. 2017 Sep 18;7(1):11751. IMM
  • Baron S, Leulmi Z, Villard C, Olaitan AO, Telke AA, Rolain JM. Inactivation of arn operon and loss of aminoarabinose on lipopolysaccharide as the cause of susceptibility to colistin in an atypical clinical isolate of Proteus vulgaris. Int J Antimicrob Agents. 2017 Dec 1. PIT2
  • Agez M, Schultz P, Medina I, Baker DJ, Burnham MP, Cardarelli RA, Conway LC, Garnier K, Geschwindner S, Gunnarsson A, McCall EJ, Frechard A, Audebert S, Deeb TZ, Moss SJ, Brandon NJ, Wang Q, Dekker N, Jawhari A. Molecular architecture of potassium chloride co-transporter KCC2 Sci Rep. 2017 Nov 28;7(1):16452. CRCM
  • Bouguenina H, Salaun D, Mangon A, Muller L, Baudelet E, Camoin L, Tachibana T, Cianférani S, Audebert S, Verdier-Pinard P, Badache A. EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions. Proc Natl Acad Sci U S A. 2017 Nov 21. CRCM
  • Lebellec L, Bertucci F, Tresch-Bruneel E, Bompas E, Toiron Y, Camoin L, Mir O, Laurence V, Clisant S, Decoupigny E, Blay JY, Goncalves A, Penel N. Circulating vascular endothelial growth factor (VEGF) as predictive factor of progression-free survival in patients with advanced chordoma receiving sorafenib: an analysis from a phase II trial of the french sarcoma group (GSF/GETO). Oncotarget. 2016 Nov 8;7(45):73984-73994. CRCM
  • Bottini S, Hamouda-Tekaya N, Mategot R, Zaragosi LE, Audebert S, Pisano S, Grandjean V, Mauduit C, Benahmed M, Barbry P, Repetto E, Trabucchi M Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq Nat Commun. 2017 Oct 30;8(1):1189 CRCM
  • Hammam K, Saez-Ayala M, Rebuffet E, Gros L, Lopez S, Hajem B, Humbert M, Baudelet E, Audebert S, Betzi S, Lugari A, Combes S, Letard S, Casteran N, Mansfield C, Moussy A, De Sepulveda P, Morelli X, Dubreuil P. Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology. Nat Commun. 2017 Nov 10;8(1):1420 CRCM
  • Sulzenbacher G, Roig-Zamboni V, Lebrun R, Guérardel Y, Murat D, Mansuelle P, Yamakawa N, Quian XX, Vincentelli R, Bourne Y, Wu LF, Alberto F Glycosylate and move! The glycosyltransferase Maf is involved in bacterial flagella formation Environ Microbiol. 2017 Oct 27. IMM
  • Tanou G, Minas IS, Scossa F, Belghazi M, Xanthopoulou A, Ganopoulos I, Madesis P, Fernie A, Molassiotis A. Exploring priming responses involved in peach fruit acclimation to cold stress. Sci Rep. 2017 Sep 12;7(1):11358. CRN2M
  • Garnier C, Devred F, Byrne D, Puppo R, Roman AY, Malesinski S, Golovin AV, Lebrun R, Ninkina NN, Tsvetkov PO. Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates. Sci Rep. 2017 Jul 28 IMM
  • Girard SD, Virard I, Lacassagne E, Paumier JM, Lahlou H, Jabes F, Molino Y, Stephan D, Baranger K, Belghazi M, Deveze A, Khrestchatisky M, Nivet E, Roman FS, Féron F. From Blood to Lesioned Brain: An In Vitro Study on Migration Mechanisms of Human Nasal Olfactory Stem Cells. Stem Cells Int. 2017:1478606. doi: 10.1155/2017/1478606. Epub 2017 Jun 18. CRN2M
  • Verzeaux L, Belloy N, Thevenard-Devy J, Devy J, Ferracci G, Martiny L, Dedieu S, Dauchez M, Emonard H, Etique N, Devarenne-Charpentier E. Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons. Sci Rep. 2017 Jul 14 CRN2M
  • Emerich BL, De Lima ME, Martin-Eauclaire MF, Bougis PE. Comparative analyses and implications for antivenom serotherapy of four Moroccan scorpion Buthus occitanus venoms: Subspecies tunetanus, paris, malhommei, and mardochei. Toxicon. 2017 Jul 13 CRN2M
  • Cartier-Michaud A, Bailly AL, Betzi S, Shi X, Lissitzky JC, Zarubica A, Sergé A, Roche P, Lugari A, Hamon V, Bardin F, Derviaux C, Lembo F, Audebert S, Marchetto S, Durand B, Borg JP, Shi N, Morelli X, Aurrand-Lions M. Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis. PLoS Genet. 2017 Jun 15 CRCM
  • Desplantes R, Lévêque C, Muller B, Lotierzo M, Ferracci G, Popoff M, Seagar M, Mamoun R, El Far O. Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor. Sci Rep. 2017 Apr 21 CRN2M
  • Delmont E, Manso C, Querol L, Cortese A, Berardinelli A, Lozza A, Belghazi M, Malissart P, Labauge P, Taieb G, Yuki N, Illa I, Attarian S, Devaux JJ. Autoantibodies to nodal isoforms of neurofascin in chronic inflammatory demyelinating polyneuropathy. Brain. 2017 May 28 CRN2M
  • Narni-Mancinelli E, Gauthier L, Baratin M, Guia S, Fenis A, Deghmane AE, Rossi B, Fourquet P, Escalière B, Kerdiles YM, Ugolini S, Taha MK, Vivier E. Complement factor P is a ligand for the natural killer cell-activating receptor NKp46. Sci Immunol. 2017 Apr 28;2(10) CRCM
  • Le Signor C, Aimé D, Bordat A, Belghazi M, Labas V, Gouzy J, Young ND, Prosperi JM, Leprince O, Thompson RD, Buitink J, Burstin J, Gallardo K. Genome-wide association studies with proteomics data reveal genes important for synthesis, transport and packaging of globulins in legume seeds. New Phytol. 2017 Mar 21. CRN2M
  • Jacquot G, Lécorché P, Malcor JD, Laurencin M, Smirnova M, Varini K, Malicet C, Gassiot F, Abouzid K, Faucon A, David M, Gaudin N, Masse M, Ferracci G, Dive V, Cisternino S, Khrestchatisky M. Optimization and in Vivo Validation of Peptide Vectors Targeting the LDL Receptor. Mol Pharm. 2016 Dec 5 CRN2M
  • Verdier-Pinard P, Salaun D, Bouguenina H, Shimada S, Pophillat M, Audebert S, Agavnian E, Coslet S, Charafe-Jauffret E, Tachibana T, Badache A. Septin 9_i2 is downregulated in tumors, impairs cancer cell migration and alters subnuclear actin filaments. Sci Rep. 2017 Mar 24;7:44976. CRCM
  • Bonacci T, Audebert S, Camoin L, Baudelet E, Iovanna JL, Soubeyran P. Regulation of NUB1 Activity through Non-Proteolytic Mdm2-Mediated Ubiquitination. PLoS One. 2017 Jan 18;12(1) CRCM
  • Gopal S, Veracini L, Grall D, Butori C, Schaub S, Audebert S, Camoin L, Baudelet E, Radwanska A, Beghelli-de la Forest Divonne S, Violette SM, Weinreb PH, Rekima S, Ilie M, Sudaka A, Hofman P, Van Obberghen-Schilling E. Fibronectin-guided migration of carcinoma collectives. Nat Commun. 2017 Jan 19;8:14105. CRCM
  • Clement R, Lignon S, Mansuelle P, Jensen E, Pophillat M, Lebrun R, Denis Y, Puppo C, Maberly SC, Gontero B. Responses of the marine diatom Thalassiosira pseudonana to changes in CO2 concentration: a proteomic approach. Sci Rep. 2017 Feb 9;7:42333. IMM/CRCM
  • Paban V, Loriod B, Villard C, Buee L, Blum D, Pietropaolo S, Cho YH, Gory-Faure S, Mansour E, Gharbi A, Alescio-Lautier B. Omics analysis of mouse brain models of human diseases. Gene 2017 Feb 5;600:90-100. PIT2
  • Viala JP, Prima V, Puppo R, Agrebi R, Canestrari MJ, Lignon S, Chauvin N, Méresse S, Mignot T, Lebrun R, Bouveret E Acylation of the Type 3 Secretion System Translocon Using a Dedicated Acyl Carrier Protein. PLoS Genet. 2017 Jan 13;13(1) IMM


  • Desuzinges Mandon E, Traversier A, Champagne A, Benier L, Audebert S, Balme S, Dejean E, Rosa Calatrava M, Jawhari A. Expression and purification of native and functional influenza A virus matrix 2 proton selective ion channel. Protein Expr Purif. 2016 Nov 5;131:42-50. CRCM
  • Guerin M, Gonçalves A, Toiron Y, Baudelet E, Audebert S, Boyer JB, Borg JP, Camoin L. How may targeted proteomics complement genomic data in breast cancer? Expert Rev Proteomics. 2016 Nov 4. CRCM
  • Mathé-Hubert H, Colinet D, Deleury E, Belghazi M, Ravallec M, Poulain J, Dossat C, Poirié M, Gatti JL. Comparative venomics of Psyttalia lounsburyi and P. concolor, two olive fruit fly parasitoids: a hypothetical role for a GH1 β-glucosidase. Sci Rep. 2016 Oct 25;6:35873. doi: 10.1038/srep35873. CRN2M
  • Ziogas V, Tanou G, Belghazi M, Diamantidis G, Molassiotis A. Characterization of β-amino- and γ-amino butyric acid-induced citrus seeds germination under salinity using nanoLC-MS/MS analysis. Plant Cell Rep. 2016 Oct 19. CRN2M
  • Jacquot G, Lécorché P, Malcor JD, Laurencin M, Smirnova M, Varini K, Malicet C, Gassiot F, Faucon A, David M, Gaudin N, Masse M, Ferracci G, Dive V, Cisternino S, Khrestchatisky M. Optimization and in Vivo Validation of Peptide Vectors Targeting the LDL Receptor. Mol Pharm. 2016 Oct 11. CRN2M
  • Martin-Eauclaire MF, Salvatierra J, Bosmans F, Bougis PE. The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension. FEBS Lett. 2016 Sep;590(18):3221-32. CRN2M
  • Martin-Eauclaire MF, Pimenta AM, Bougis PE, De Lima ME. Potassium channel blockers from the venom of the Brazilian scorpion Tityus serrulatus. Toxicon. 2016 Sep 1;119:253-65. CRN2M
  • Tadi SK, Tellier-Lebègue C, Nemoz C, Drevet P, Audebert S, Roy S, Meek K, Charbonnier JB, Modesti M. PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF. Cell Rep. 2016 Oct 4;17(2):541-555. CRCM
  • Roncagalli R, Cucchetti M, Jarmuzynski N, Grégoire C, Bergot E, Audebert S, Baudelet E, Menoita MG, Joachim A, Durand S, Suchanek M, Fiore F, Zhang L, Liang Y, Camoin L, Malissen M, Malissen B. The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med. 2016 Sep 19. CRCM
  • Prioretti L, Lebrun R, Gontero B, Giordano M. Redox regulation of ATP sulfurylase in microalgae. Biochem Biophys Res Commun. 2016 Sep 6. IMM
  • Tchoghandjian A, Soubéran A, Tabouret E, Colin C, Denicolaï E, Jiguet-Jiglaire C, El-Battari A, Villard C, Baeza-Kallee N, Figarella-Branger D. Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152. Cell Death Dis. 2016 Aug 4;7(8) PIT2
  • Peltier J, Roperch JP, Audebert S, Borg JP, Camoin L. Quantitative proteomic analysis exploring progression of colorectal cancer: Modulation of the serpin family. J Proteomics. 2016 Aug 2;148:139-148 CRCM
  • Thieulin-Pardo G, Schramm A, Lignon S, Lebrun R, Kojadinovic M, Gontero B. The intriguing CP12-like tail of adenylate kinase 3 from Chlamydomonas reinhardtii. FEBS J. 2016 Jul 15. IMM
  • Boughanemi S, Lyonnet J, Infossi P, Bauzan M, Kosta A, Lignon S, Giudici-Orticoni MT, Guiral M. Microbial oxidative sulfur metabolism: biochemical evidence of the membrane-bound heterodisulfide reductase-like complex of the bacterium Aquifex aeolicus. FEMS Microbiol Lett. 2016 Aug;363(15) IMM
  • Daulat AM, Bertucci F, Audebert S, Sergé A, Finetti P, Josselin E, Castellano R, Birnbaum D, Angers S, Borg JP. PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2. Dev Cell. 2016 May 5 CRCM
  • Tabouret E, Bertucci F, Pierga JY, Petit T, Levy C, Ferrero JM, Campone M, Gligorov J, Lerebours F, Roché H, Bachelot T, van Laere S, Ueno NT, Toiron Y, Finetti P, Birnbaum D, Borg JP, Viens P, Chinot O, Gonçalves A. MMP2 and MMP9 serum levels are associated with favorable outcome in patients with inflammatory breast cancer treated with bevacizumab-based neoadjuvant chemotherapy in the BEVERLY-2 study. Oncotarget. 2016 Apr 5;7(14):18531-40 CRCM
  • Ravachol J, de Philip P, Borne R, Mansuelle P, Maté MJ, Perret S, Fierobe HP. Mechanisms involved in xyloglucan catabolism by the cellulosome-producing bacterium Ruminiclostridium cellulolyticum. Sci Rep. r2016 Mar 7;6:22770. IMM
  • Devaux JJ, Miura Y, Fukami Y, Inoue T, Manso C, Belghazi M, Sekiguchi K, Kokubun N, Ichikawa H, Wong AH, Yuki N. Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy. Neurology 2016 Mar 1;86(9):800-7. CRN2M
  • Minas IS, Tanou G, Karagiannis E, Belghazi M, Molassiotis A. Coupling of Physiological and Proteomic Analysis to Understand the Ethylene- and Chilling-Induced Kiwifruit Ripening Syndrome. Front Plant Sci. 2016 Feb 15;7:120. CRN2M
  • Ainalidou A, Tanou G, Belghazi M, Samiotaki M, Grigorios D, Molassiotis A, Karamanoli K. Integrated analysis of metabolites and proteins reveal aspects of the tissue-specific function of synthetic cytokinin in kiwifruit development and ripening. J Proteomics 2016 Feb 15;7:120. CRN2M
  • Le Laz S, Kpebe A, Bauzan M, Lignon S, Rousset M, Brugna M. Expression of terminal oxidases under nutrient-starved conditions in Shewanella oneidensis: detection of the A-type cytochrome c oxidase. Sci Rep. 2016 Jan 27;6:19726. IMM
  • Puvirajesinghe TM, Bertucci F, Jain A, Scerbo P, Belotti E, Audebert S, Sebbagh M, Lopez M, Brech A, Finetti P, Charafe-Jauffret E2,3,4,5, Chaffanet M, Castellano R, Restouin A, Marchetto S, Collette Y, Gonçalvès A, Macara I, Birnbaum D, Kodjabachian L, Johansen T, Borg JP. Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer. Nat Commun. 2016 Jan 12;7:10318. CRCM

Some Achievements

Some Achievements

A Selection Of Our Succesful Works.
Click a keyword below.


Marseille Proteomics Facility
A regional multisite platform

Marseille Protéomique (MaP) is a three-site proteomics facility, which besides mass spectrometry offers a wide panel of complementary techniques for protein identification and characterization, biomolecule quantification, biomarker discovery, binding studies imaging, structural proteomics and bioinformatics services. MaP is the main proteomics facility in the Région Sud Provence-Alpes-Côte d'Azur (PACA) region, which offers collaborative and fee-for-service opportunities for basic and clinical research but also for industry. MaP covers a large experimental field from oncology, immunology, and microbiology specific of each MaP component. PACA is in the third position in France for life science research and this dynamic scientific and medical environment brings to MaP numerous opportunities of collaborations at the regional level.

MaP was founded in 2007, certified in 2008 by the National Infrastructures in Biology, Health and Agronomy IBiSA and certified in 2013 by Aix-Marseille Université. It is composed of three platforms located at three different sites in proximity with the major CNRS, INSERM, Aix-Marseille Université research centres as well as the “for non profite private health establishments of collective interest” (Etablissement de Santé Privé d'Intérêt Collectif (ESPIC)) Paoli Calmettes Institute (Centre de lutte contre le cancer (CLCC)).

Institut Paoli-Calmettes

  • Quantitative Proteomics
    by LC-MS
  • Research and identification of new protein complexes
  • Biomarker research in cancer and immunology using quantitative proteomic approaches

Campus CNRS Joseph Aiguier

  • Structural Proteomics (native ESI-MS and MALDI-ToF-MS, Hydrogen/Deuterium Exchange and MS, Conformational Analysis by Ion Mobility-MS)
  • Chemical and Post-Translational Modifications
  • Protein sequencing
    by Edman degradation

Campus Santé Timone

  • MS imaging for protein or drug localization in tissues
  • Top down protein analysis: characterisation without trypsic digestion of N and C extremities
  • Determination and characterisation of medicinal products and therapeutic antibodies


  • Management committee
    The management committee consists of the members of the Executive Board, the operational manager, the two technical managers and the quality manager.
  • Operational committee
    Each month the staff members of all the sites meet around the technical and operational managers.
  • Scientific advisory board
    The management committee takes advices from external experts, with a one-day meeting every three-four years. The next Scientific Advisory Board is scheduled in 2020.



Our Team

Our Team

Marseille Proteomics staff.

Stéphane Audebert

Technical Manager

Manel Khelil Berbar


Emilie Baudelet


Jean-Paul Borg

Scientific manager

Luc Camoin

Operational manager

Patrick Fourquet


Marc-Antoine Gérault


Anthony Gonçalvès


Samuel Granjeaud

Bioinformatics manager

Daniel Lafitte

Scientific manager

Régine Lebrun

Technical Manager

Pascal Mansuelle

Quality manager

Brigitte Meunier

Scientific manager

Thérèse Schembri


Yves Toiron


Christophe Verthuy


Emmanuel Wafo


Contact us

Contact us

If you want to submit a project to the MaP platform, please fill the form below to send us an email. Please describe in detail your project and provide key information about your project: biological questions, hypotheses, reference lists, similar proteomics studies (if known). Possibly, you can also mention the proteomic strategy that you think is best suited to answer your biological questions.
You will be contacted by MaP staff within two weeks to schedule a preliminary meeting at which the following points will be discussed: scientific and technical approaches prior to proteomics analysis, feasibility of the project, duration and resources (human, financial, technical). The MaP team will advise you on the best proteomics strategy to use and on the nature of our expertise that we can offer you.
It is important to note that for applications for funding (ANR and others), we can depending on our participation in the project appear as a partner. In any case, it is strongly advised to contact us as soon as possible to discuss the project and allow us to add our expertise and added value in proteomics to the project.


Marseille, France